Table 1. . Randomized trials of sublingual immunotherapy for food allergy.

Study (year)	Allergen	Study participants (active treatment)	Median participant age (years)	Maintenance dose (mg)	Treatment duration	Treatment responders (desensitization)	Median cumulative tolerated dose at challenge (mg)	% doses with adverse effects	Treatment group dropouts	Dropouts related to adverse events	Ref.
Enrique (2005)	Hazelnut†	12	29.2‡	13.25	8–12 weeks	Not reported¶	Fivefold increase	7.6	1	0	[37]
Fernández-Rivas (2009)	Peach†	37	29.1‡	0.01§	6 months	Not reported¶	Three- to ninefold increase	39.8	4	1	[38]
Fleischer (2013)	Peanut	20	15	1.386	44 weeks	14/20 (70%)#	371	37	5	1	[40]
Narisety (2015)	Peanut	10	11	3.7	12 months	7/10 (70%)#	496	9	1	1	[43]
Kim (2011)	Peanut	11	5.8	2	6 months	Not reported¶	1710	11.5	0	0	[44]
Kim (2019)	Peanut	48	6.5	2	3–5 years	32/48 (67%)††	1750	4.8	11	2	[45]

^†Includes patients with oral allergy syndrome.

^‡Mean age.

^§Pru P 3 antigen quantity.

^¶No threshold for responders was defined in this study.

^#Responders defined as tenfold increase from baseline [40,43] or 5 g oral food challenge [40].

^††Responders defined as tolerating 750 mg oral food challenge.