Table 3:

Cause of postoperative severe morbidity (CTCAE grade ≥ 3) before/after propensity score matching

	Before matching				After matching
	MIS		Thoracotomy		MIS		Thoracotomy
System organ class and adverse events	n = 607		n = 696		n = 338		n = 338		P
Respiratory, thoracic and mediastinal disorders	20	(3.3)	56	(8.0)	9	(2.7)	20	(5.9)	0.056
Adult respiratory distress syndrome/respiratory failure	6	(1.0)	24	(3.4)	4	(1.2)	8	(2.4)
Pneumonitis/lung infectiona	3	(0.5)	8	(11)	0	(0.0)	2	(0.6)
Pneumothorax	4	(0.7)	14	(2.0)	1	(0.3)	6	(18)
Bronchopleural fistula /pleural infectiona	5	(0.8)	4	(0.6)	3	(0.9)	1	(0.3)
Chylothorax	2	(0.3)	4	(0.6)	1	(0.3)	2	(0.6)
Others	0	(0.0)	2	(0.3)	0	(0.0)	1	(0.3)
Cardiac and vascular disorders	5	(0.8)	14	(2.0)	3	(0.9)	8	(2.4)	0.2
Acute coronary syndrome	2	(0.3)	1	(0.1)	2	(0.6)	0	(0.0)
Atrial fibrillation	0	(0.0)	6	(0.9)	0	(0.0)	2	(0.6)
Thromboembolic event	3	(0.5)	5	(0.7)	1	(0.3)	5	(1.5)
Others	0	(0.0)	2	(0.3)	0	(0.0)	1	(0.3)
Nervous system disorders	2	(0.3)	2	(0.3)	2	(0.6)	1	(0.3)	¶
Stroke	1	(0.2)	2	(0.3)	1	(0.3)	1	(0.3)
Others	1	(0.2)	0	(0.0)	1	(0.3)	0	(0.0)
Renal and urinary disorders	2	(0.3)	6	(0.9)	1	(0.3)	1	(0.3)	¶
Acute kidney injury	1	(0.2)	5	(0.7)	0	(0.0)	1	(0.3)
Urinary tract infectiona	1	(0.2)	1	(0.1)	1	(0.3)	0	(0.0)
Gastrointestinal and hepatobiliary disorders	1	(0.2)	2	(0.3)	0	(0.0)	0	(0.0)	¶
Colitis	0	(0.0)	1	(0.1)	0	(0.0)	0	(0.0)
Ileus	0	(0.0)	1	(0.1)	0	(0.0)	0	(0.0)
Others	1	(0.2)	0	(0.0)	0	(0.0)	0	(0.0)
Postoperative bleeding	2	(0.3)	1	(0.1)	1	(0.3)	0	(0.0)	¶
Other category	7	(1.2)	2	(0.3)	4	(1.2)	0	(0.0)	¶
Anemia	3	(0.5)	1	(0.1)	0	(0.0)	1	(0.3)
Delirium	0	(0.0)	1	(0.1)	0	(0.0)	1	(0.3)
Wound infection	2	(0.3)	0	(0.0)	2	(0.6)	0	(0.0)
Others	2	(0.3)	0	(0.0)	2	(0.6)	0	(0.0)

Data are number (%)

Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events

^aIncluded in “infections and infestations” in the CTCAE category.

^¶No statistical comparison due to small number of events.