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. 2020 Aug 1;2020:4074832. doi: 10.1155/2020/4074832

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Copyright © 2020 Wei Huang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SCFAs prevented the renal dysfunction and kidney injury. Urine ACR (a) of T2D mice were measured every 2 weeks, and blood urea nitrogen (BUN) (b), serum creatinine (SCr) (c), and serum cystatin C (d) were assayed at the 20th week of the experiment. Histopathological examination of renal tissues was by H&E, PAS, and Masson's trichrome staining (400x) (e). Mesangial expansion (f), glomerular tuft (g), and the accumulation of collagen (h) were measured. Ac: acetate; Pr: propionate; But: butyrate; ^∗p < 0.05 compared with the NC group; ^#p < 0.05 compared with the T2D group; ^&p < 0.05 compared with the Ac or Pr group.