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. 2020 Aug 1;2020:4074832. doi: 10.1155/2020/4074832

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Copyright © 2020 Wei Huang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SCFAs inhibited T2D-induced NF-κB activation and regulate GPR43-β-arrestin-2 signaling. (a) Western blotting revealed the expression of I-κBα, p-NF-κBp65, MCP-1, and IL-1β in T2D kidney tissue after SCFA treatment. (b, c) qRT-PCR of GPR43, GPR41, β-arrestin-2, and β-arrestin-1 in kidney tissue after SCFA treatment. (d) Western blotting-based assays for the expression of GPR43 and β-arrestin-2 in kidney tissue after SCFA treatment. (e) Immunohistochemistry- (400x) based assays for the expression of p-NF-κBp65, MCP-1, GPR43, and β-arrestin-2 after SCFA treatment. Ac: acetate; Pr: propionate; But: butyrate; ^∗p < 0.05 compared with the NC group; ^#p < 0.05 compared with the T2D group; ^&p < 0.05 compared with the Ac or Pr group.