Fig. 4.

Exploration of downstream molecular mechanism of POLE2 in ESCC cells. a Human apoptosis antibody array analysis was performed in Eca-109 cells with or without POLE2 knockdown. b Differences in human apoptotic antibody array were analyzed in Eca-109 cells regardless of POLE2 knockdown. c Densitometric analysis was performed and the gray values of differentially expressed proteins were shown. d The expression of pathway was observed by western blot in Eca-109 cells. The data were expressed as mean ± SD (n = 3), *P < 0.05, **P < 0.01, ***P < 0.001