Table 1.
Characteristics of patients with POI, DOR and control women
| Parameter | POI | DOR | Controlb | P1a | P2a | P3a |
|---|---|---|---|---|---|---|
| N | 124 | 57 | 111 | |||
| Enrolled age, yrs, mean ± SD | 31.3 ± 6.5 | 32.5 ± 3.8 | 48.0 ± 6.1 | < 0.001 | < 0.001 | 0.149 |
| Age at menarche, yrs, mean ± SD | 13.4 ± 1.6 | 13.2 ± 1.2 | 0.395 | |||
| Age at menopause, yrs, mean ± SD | 28.4 ± 7.1 | NA | 50.7 ± 3.0 | < 0.001 | ||
| BMI (kg/m2), mean ± SD | 22.1 ± 3.8 | 21.6 ± 3.5 | 25.0 ± 3.2 | < 0.001 | < 0.001 | 0.351 |
| Currently Smoking, No. (%) | 3 (2.7) | 1 (1.8) | 2 (1.8) | 0.307 | 0.565 | 0.593 |
| FSH (IU/l), mean ± SD | 81.7 ± 35.8 | 15.0 ± 4.8 | 30.5 ± 30.8 | < 0.001 | < 0.001 | < 0.001 |
| Estradiol (pg/ml), mean ± SD | 33.3 ± 38.4 | 46.4 ± 27.6 | 87.7 ± 125.1 | < 0.001 | 0.001 | 0.027 |
| AMH (ng/ml), mean ± SD | 0.06 ± 0.18 | 0.80 ± 0.76 | < 0.001 | |||
| FMR1 Allele1, mean ± SD | 29.8 ± 2.1 | 29.3 ± 3.5 | 29.9 ± 3.8 | 0.694 | 0.281 | 0.330 |
| Median [IQR] | 29 [29,30] | 30 [29,31] | 30 [29,31] | |||
| FMR1 Allele2, mean ± SD | 33.4 ± 7.7 | 32.2 ± 4.1 | 33.2 ± 5.0 | 0.847 | 0.202 | 0.290 |
| Median [IQR] | 30 [30,36] | 31 [30, 34.5] | 31 [30,37] |
aP1 indicated POI versus controls, P2 indicated DOR versus controls, and P3 indicated POI versus DOR
b the characteristics presented in the Table were results at baseline assessment of the women in the control group
Abbreviation: POI Premature ovarian insufficiency, DOR Diminished ovarian reserve, FSH Follicle-stimulating hormone, AMH Anti-mullerian hormone, SD Standard deviation, BMI Body mass index, IQR Interquartile range, NA Not applicable