Table 2.
Univariate and multivariate Cox proportional hazard models for overall survival
| Variable | Univariate Analysis HR (95% CI) |
P value | Multivariable Analysis HR (95% CI)a |
P value |
|---|---|---|---|---|
| Gender | ||||
| Female | N/A | N/A | 1.0 (Reference) | |
| Male | N/A | N/A | 1.33 (1.00–1.78) | .053 |
| Age | ||||
| ≤ 70 | N/A | N/A | 1.0 (Reference) | |
| > 70 | N/A | N/A | 1.41 (1.01–1.97) | .04 |
| Pathologic Stage | ||||
| T0 | N/A | N/A | 1.0 (Reference) | |
| T1 | N/A | N/A | 1.36 (0.53–3.54) | .53 |
| T2 | N/A | N/A | 2.85 (1.33–6.12) | .007 |
| T3 | N/A | N/A | 3.13 (1.44–6.83) | .004 |
| CCI | ||||
| 0–3 | N/A | N/A | 1.0 (Reference) | |
| 4+ | N/A | N/A | 1.63 (1.11–2.40) | .01 |
| NLR | ||||
| < 5 | 1.0 (Reference) | 1.0 (Reference) | ||
| ≥ 5 | 1.80 (1.22–2.64) | .003 | 2.13 (1.41–3.22) | .002 |
| PLR | ||||
| < 144.4 | 1.0 (Reference) | N/A | N/A | |
| ≥ 144.4 | 1.02 (0.78–1.34) | .889 | N/A | N/A |
| LMR | ||||
| < 2.9 | 1.0 (Reference) | N/A | N/A | |
| ≥ 2.9 | 0.82 (0.63–1.08) | .156 | N/A | N/A |
| Perineural Invasion | ||||
| No | N/A | N/A | 1.0 (Reference) | |
| Yes | N/A | N/A | 1.51 (0.99–2.31) | .055 |
| Complication Grade (3–4)b | N/A | N/A | 2.37 (1.57–3.57) | <.0001 |
| Positive Nodes | N/A | N/A | 1.07 (1.03–1.12) | .002 |
amodel includes: age, gender, pathologic stage, CCI, complication score, NLR, nodal and perineural invasion status. b Clavien-Dindo Classification of Surgical Complications
Abbreviations: CCI Charlson Comorbidity Score, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio