Table 3.
Univariate and multivariate Cox proportional-hazard models for recurrence-free survival
| Variable | Univariate Analysis HR (95% CI) |
P value | Multivariable Analysis HR (95% CI)a |
P value |
|---|---|---|---|---|
| Gender | ||||
| Female | N/A | 1.0 (Reference) | ||
| Male | N/A | N/A | 1.25 (0.95–1.65) | .11 |
| Pathologic Stage | ||||
| T0 | N/A | 1.0 (Reference) | ||
| T1 | N/A | N/A | 1.29 (0.55–3.00) | .56 |
| T2 | N/A | N/A | 2.41 (1.21–4.80) | .01 |
| T3 | N/A | N/A | 2.60 (1.27–5.29) | .009 |
| CCI | ||||
| 0–3 | N/A | 1.0 (Reference) | ||
| 4+ | N/A | N/A | 1.48 (1.05–2.09) | .02 |
| NLR | ||||
| < 5 | 1.0 (Reference) | 1.0 (Reference) | ||
| ≥ 5 | 1.65 (1.14–2.39) | .008 | 2.20 (1.43–3.39) | .0003 |
| PLR | ||||
| < 144.4 | 1.0 (Reference) | N/A | ||
| ≥ 144.4 | 0.94 (0.73–1.22) | .64 | N/A | N/A |
| LMR | ||||
| < 2.9 | 1.0 (Reference) | N/A | ||
| ≥ 2.9 | 0.90 (0.69–1.16) | .41 | N/A | N/A |
| Perineural Invasion | ||||
| No | N/A | 1.0 (Reference) | ||
| Yes | N/A | N/A | 1.61 (1.08–2.41) | .02 |
| Complication Grade (3–4)b | N/A | N/A | 1.64 (1.10–2.44) | .01 |
| Positive Nodes | N/A | N/A | 1.08 (1.03–1.12) | .0003 |
Abbreviations: CCI Charlson Comorbidity Score, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio
a model includes: age, gender, pathologic stage, CCI, complication score, NLR, nodal and perineural invasion status
b Clavien-Dindo Classification of Surgical Complications