Table 2.
2D and 3D in vitro models for studying obesogens. Note: -- under Matrix indicates a 2D cell culture study
| Matrix | Cell Type | Obesogen | Source |
|---|---|---|---|
| – | 3T3-L1 (murine preadipocyes) | Tributyltin (TBT) | [42, 43, 94–99] |
| Bisphenol A (BPA) | [97–99] | ||
| Bisphenol S (BPS) | [102] | ||
| Bisphenol A diglycidyl ether (BADGE) | [100] | ||
| Triphenyltin | [95] | ||
| Dioctyl sodium sulfosuccinate (DOSS) | [52] | ||
| Geneistein & naringenin | [103] | ||
| Phthalate monoesters | [32] | ||
| 4-nonylphenol (NP) | [101] | ||
| Mono-ethylhexyl phthalate (MEHP) | [50] | ||
| Flavanone | [104] | ||
| Bixin, norbixin | [105] | ||
| Emodin | [106] | ||
| C2C12 (murine) | Mono-ethylhexyl phthalate (MEHP) | [50] | |
| HELA (human) | Mono-ethylhexyl phthalate (MEHP) | [50] | |
| Human embryonic kidney cells (HEK293C) | Dioctyl sodium sulfosuccinate (DOSS) | [52] | |
| HepG2 (human liver carcinoma cells) | Bisphenol A (BPA), Bisphenol S (BPS) | [102] | |
| Human adipose-derived stem cells (hASCs) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
| Tributyltin (TBT) | [44] | ||
| Murine adipose derived stem cells (mASCs) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
| Tributyltin (TBT) | [44] | ||
| Fao (murine hepatoma cells) | Phthalate monoesters | [32] | |
| COS (monkey kidney-derived cells) | Bisphenol A (BPA), Bisphenol A diglycidyl ether (BADGE) | [102] | |
| MBzP, MBuP | [50] | ||
| Mono-ethylhexyl phthalate (MEHP) | [50, 107] | ||
| THP-1 macrophages (human) | Psi-baptigenin, hesperidin | [108] | |
| TARM-Luc (human, transfected T47-D epithelial cells) | Monosodium glutamate (MSG) | [109] | |
| KS483 (murine calvaria) | Soy phytoestrogen genistein | [110] | |
| C57BL/6 (murine–derived bone marrow stromal cells) | Firemaster 550 | [51] | |
| collagen embedded silk scaffolds | Human embryonic-derived stem cells (hESCs) | Tributyltin (TBT), Bisphenol A (BPA), Bisphenol S (BPS) | [111] |
| silk scaffolds | Human adipose-derived stem cells (hASCs), Human umbilical vein endothelial cells (HUVECs) | – | [112] |
| silk fibroin matrices | Human adipose-derived stem cells (hASCs) | – | [113] |
| collagen type 1 | OP9 (murine mesenchymal stromal pluripotent cells), HaCaT (human keratinocytes) | Super Hatomugi (SPH) | [114] |
| bacterial nanocellulose | Murine mesenchymal stem cells (mMSCs) | – | [115] |
| fibrous polyethylene teraphthalate scaffolds | 3T3-L1 (murine preadipocyes) | – | [116] |
| low-shear rotary bioreactor | Murine adipose-derived stem cells (mASCs) | – | [117] |
| polyglycolic acid fiber meshes | 3T3-L1 (murine preadipocyes) | – | [118] |
| adipospheres created via magnetic nanoparticle levitation system | 3T3-L1 (murine preadipocyes) | – | [119] |