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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neurobiol Dis. 2020 Jul 2;143:105006. doi: 10.1016/j.nbd.2020.105006

Figure 1. Experimental design for these studies and behavioral assessment of motor functions.

Figure 1.

(A) Experimental design for electrophysiology, behavioral, histopathological and molecular studies. The TAF1-edited animals showed behavior deficits compared to naïve and gRNA-control group animals. The TAF1-edited showed increased beam crossing time (B) and increased foot slips errors (C) in the beam walking test. In addition, grooming was increased in the TAF1-edited rats compared to the other groups (D). SAK3 administration to the TAF1 edited animals showed improved the TAF1 edited behavioral abnormalities. Data are shown as mean ± S.E.M., n=24 per experimental condition. *p < 0.05 versus; naïve, #p < 0.05 versus gRNA-control (ANOVA followed by Tukey’s test). The experiments were conducted in an investigator blinded manner.