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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neurobiol Dis. 2020 Jul 2;143:105006. doi: 10.1016/j.nbd.2020.105006

Figure 3. SAK3 rescued the decreased frequency of spontaneous excitatory post synaptic current (sEPSCs) in TAF1 edited Purkinje cells.

Figure 3.

(A) Photomicrograph of cerebellar slice preparation with a progressive zoom with the rightmost panel showing positioning of the recording electrode to this region. (B) Representative recording traces of cells from the indicated groups. The cumulative probability of amplitude (C) and inter-event interval (E). Summary of amplitudes (D) and frequencies (F) of sEPSCs for the indicated groups are shown. Data are shown as mean ± S.E.M., n=12 Purkinje cells from at least 2 animals per experimental condition. *p < 0.05 versus; gRNA-control, &p < 0.05 versus gRNA-TAF1 (ANOVA followed by Tukey’s test). The experiments were conducted in an investigator-blinded manner.