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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neurobiol Dis. 2020 Jul 2;143:105006. doi: 10.1016/j.nbd.2020.105006

Figure 5. The effects of SAK3 on mediators of apoptosis.

Figure 5.

(A) Representative Western analysis is shown from cerebellum samples from animals from each of the experimental conditions. Note increased cleaved caspase 3 in gRNA-TAF1 edited animals and diminished cleaved caspase 3 levels in gRNA-TAF1. Note increased BAX levels in gRNA-TAF1 edited animals, whereas SAK3 reduced BAX levels to control levels (B). (C&D) Quantification of Western analysis form two independent experiments. Data shown are mean + SEM, n = 6 animals per each experimental condition. *p < 0.05 versus gRNA-control water and RNA-control SAK3 group; # p< 0.05 versus gRNA-TAF1 water group (ANOVA followed by Tukey’s test).