Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Neurobiol Dis. 2020 Jul 2;143:105006. doi: 10.1016/j.nbd.2020.105006

Figure 6. The effects of SAK3 on BDNF and Akt phosphorylation expression in the cerebellum of TAF1 edited animals.

Figure 6.

(A) Expression of BDNF was decreased in TAF1-edited animals (Av) as compared to all other experimental groups (Ai-iv). SAK3 administration to the TAF1 edited animals shows increased number of BDNF-positive cells as compared to TAF1 edited group (Avi & v). (C) Expression of p-AKT was decreased in TAF1-edited animals (Cv) as compared to all other experimental groups (Ci-iv). SAK3 administration to the TAF1 edited animals shows increased expression of p-AKT as compared to TAF1 edited group (Cvi & v). Summary of BDNF expression (B) and expression of p-AKT (D) in each of the experimental conditions. Data are shown as mean ± S.E.M., n=12 fields per animal, 4 animals per experimental condition. *p < 0.05 versus; naïve, #p < 0.05 versus gRNA-control (ANOVA followed by Tukey’s test). Scale bars: 200 μm. The experiments were conducted in an investigator-blinded manner.