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. 2020 Aug 12;20:389. doi: 10.1186/s12935-020-01360-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CircOSBPL10 upregulated UBE2Q1 expression by competitively binding with miR-1179 in CC. a Venn diagram showed the overlaps of potential miR-1179 targets predicted by PITA, microT, PicTar, miRmap. b The binding capacity between miR-1179 and four mRNAs was verified through RNA pull-down assay. c, d The expression of UBE2Q1 in SiHa and HeLa cells transfected with different plasmids was detected via RT-qPCR and western blot. e UBE2Q1 expression in CC cell lines and H8 cells was detected via RT-qPCR. f The binding sites between UBE2Q1 and miR-1179 obtained from starBase were displayed. g The interaction between UBE2Q1 and miR-1179 was validated by luciferase reporter assay. h RIP analysis revealed that circOSBPL10, miR-1179 and UBE2Q1 co-existed in RISCs (RNA-induced silencing complexes). i RT-qPCR and western blot were utilized to detect the expression of UBE2Q1 in indicated cells. **P < 0.01