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. 2020 Aug 12;20:389. doi: 10.1186/s12935-020-01360-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — FOXA1 activated circOSBPL10 expression in CC. a The efficacy of FOXA1 knockdown and overexpression in SiHa and HeLa cells was obtained through RT-qPCR analysis. b The expression of circOSBPL10 in different groups was detected by RT-qPCR. c The DNA motif of FOXA1 was obtained from JASPAR database. d Full-length of OSBPL10 promoter was fragmented into 5 pieces (P1-5), and JASPAR predicted a potential binding site for FOXA1 to OSBPL10 promoter at P4 region. e ChIP assay proved that the P4 region of OSBPL10 promoter was recognized by FOXA1 in both SiHa and HeLa cells. f The interaction between OSBPL10 promoter and FOXA1 at above predicted sites was testified by luciferase reporter assay. **P < 0.01