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. 2020 Jan 13;41(8):1030–1037. doi: 10.1093/carcin/bgaa002

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Published by Oxford University Press 2020.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Location of the ESR1 (ERα) binding sites within the APOBEC3B genomic region on chromosome 22. Genome-wide maps of transcription factor binding sites were generated by ENCODE based on ChIP-sequencing and viewed using the UCSC genome browser (GRCh37/hg19). (A) The 67 kb genomic region that includes A3A and A3B genes and SNPs rs1014971 and rs17000526, which are located within the A3B enhancer. (B) Zoom-in view of the 1.7 kb genomic region centered on the ESR1 site 1, which is mapped just 6 bp upstream of rs17000526 in the ER+ Ishikawa endometrial cancer cell line. ESR1 binding sites are highlighted in blue.