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. 2019 Nov 19;41(8):1123–1133. doi: 10.1093/carcin/bgz188

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — ISOC1 expression in CRC samples and cell lines. (A) Caspase-3/7 activity assay. Statistical analysis of caspase-3/7 activity in the shCtrl, shISOC1-1 and shISOC1-2 groups. (B) Cell apoptosis assay. Representative flow cytometric images in the shCtrl, shISOC1-1 and shISOC1-2 groups. (C) Western blot assay. The protein expression levels of cleaved PARP-1 and cleaved caspase-3 and -9 were increased in the shISOC1 (shISOC1-1) group compared with the shCtrl group, whereas the expression levels of pro-PARP-1 and pro-caspase-3 and -9 were decreased in the shISOC1 group compared with the shCtrl group. (D) Wound healing assay. The migration rate is derived from the ratio of the difference in wound width at different times to the initial wound width. (E) Transwell migration assays. The error bars represent the standard deviation. *P < 0.05, **P < 0.01.