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. 2020 Aug 11;8(2):e000949. doi: 10.1136/jitc-2020-000949

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Microarray analysis of in vitro generated MDSC. Whole transcriptome of MDSC differentiated in vitro with IL-6 and GM-CSF versus GM-CSF only was analyzed by microarray. (A) Volcano plot shows differentially expressed genes. Red line indicates significance threshold. (B) Heatmap showing differential expression of selected genes important for MDSC functions. (C) Normalized enrichment score (NES) of important significantly regulated pathways found by GSEA pathway analysis using KEGG pathways. GM-CSF, granulocyte macrophage colony-stimulating factor; GSEA, gene set enrichment analysis; IL, interleukin; MDSC, myeloid-derived suppressor cells.