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. 2020 Aug 11;8(2):e000949. doi: 10.1136/jitc-2020-000949

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Growth of IL-6 overexpressing Ret melanoma cells in vivo. Ret melanoma cells were transduced to overexpress IL-6 and were injected subcutaneously into C57BL/6 mice. (A) Tumor growth is presented as tumor volume in mm³ (mean±SEM; n=4). (B–F) At day 21, tumor weight was measured, and tumor cell suspension was analyzed by flow cytometry (mean±SD; n=4). (B) Tumor weight expressed in mg. (C) CD11b⁺Gr1⁺ MDSC are shown as the percentage within leukocytes. (D) CCR5⁺ MDSC are shown as the percentage among total MDSC. (E) CD8⁺ T cells are presented as the percentage within leukocytes. (F) CD69⁺ cells are shown as the percentage within total CD8⁺ T cells. *p<0.05, **p<0.01. CCR5, C–C chemokine receptor; EV, extracellular vesicle; IL, interleukin; MDSC, myeloid-derived suppressor cells; OE, overexpressing.