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. 2020 Aug 11;8(1):e001338. doi: 10.1136/bmjdrc-2020-001338

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Forty-eight DMPs in obese groups in multiple phases of analyses (Phase I: Discovery and Phase II and III: Replication). A total of 22 hypermethylated and 26 hypomethylated CpGs and annotated genes in obesity were categorized into four gene-groups from IPA results—Gene-group A (lipid metabolism, small molecule biochemistry, cellular compromise), B (lipid metabolism, small molecule biochemistry, vitamin and mineral metabolism), C (cell-mediated immune response, cellular development, cellular function and maintenance), and D (uncategorized) from IPA results. DMPs were further prioritized with intertissue (fat and blood) and/or interage (childhood and adult) consistency and methylation-expression correlation in fat tissue. DEG, differentially expressed genes; DMPs, differentially methylated CpGs; FDR, false discovery rate.