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. Author manuscript; available in PMC: 2020 Aug 12.
Published in final edited form as: Cell Chem Biol. 2020 Jan 2;27(1):94–104.e5. doi: 10.1016/j.chembiol.2019.12.007

Figure 1. Developing a high-content screen for interleukin-12 soliciting agents.

Figure 1.

a, Graphic abstract of screen. Bone marrow cells were isolated from an IL-12 reporter mouse and differentiated into dendritic cells, which were subsequently used for a high-content screen. b, Image analysis pipeline. After nuclear thresholding, YFP scores were computed and used to rank order compounds.