Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

. Author manuscript; available in PMC: 2020 Aug 12.

Published in final edited form as: Cell Rep. 2020 Jun 30;31(13):107843. doi: 10.1016/j.celrep.2020.107843

	All Subjects			Subjects with QC-passing Myeloid Profiles

	Control	AD	p^*	Control	AD	p^*

N	21	21		15	10

Male	13 (62%)	10 (48%)	0.536	10 (67%)	5 (50%)	0.442

ApoE4+	0 (0%)	9 (43%)	0.00132	0 (0%)	6 (60%)	0.00119

Age	80 (71 –88)	79 (72–84)	0.943	83 (67–89.5)	78.5 (72.8–83.2)	0.938

PMI	3 (2.5–3.25)	3 (2.33–3.08)	0.519	3 (2.75–3.2)	2.92 (2.2–3)	0.619

Last MMSE	28.5 (27.8–29)	1 (0–4)	6.52E-27	28.5 (27.8–29.2)	0.5 (0–5.5)	5.39E-11

p values for Sex (Male) and ApoE4 status from Fisher’s Exact Test, others from Student’s t test. Median and interquartile range shown for Age/Post-mortem interval (PMI)/Last Mini-Mental State Exam (MMSE).