Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

. Author manuscript; available in PMC: 2020 Aug 12.

Published in final edited form as: Cell Rep. 2020 Jun 30;31(13):107843. doi: 10.1016/j.celrep.2020.107843

	GSE95587 (previously published)			GSE125583 (new subjects in this study)

	Control	AD	P^*	Control	AD	P^*

N	33	84		42	158

Male	23 (70%)	42 (50%)	0.0644	19 (45%)	86 (55%)	0.3

ApoE4+	8 (24%)	38 (45%)	0.0574	5 (12%)	85 (54%)	5.29E-07

Age	82 (80–90)	87 (81–91)	0.471	89 (84.2–91)	84 (77–88)	7.45E-06

Last MMSE	29 (28–29)	17 (7–22)	2.10E-23	28.5 (27–30)	14 (6–21)	1.06E-47

P values for Sex (Male) and ApoE4 status from Fisher’s Exact Test, others from Student’s t test. Median and interquartile range shown for Age and Last MMSE.