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. 2020 Aug 12;25(10):1822–1838. doi: 10.1016/j.drudis.2020.08.002

Figure 3.

Figure 3

Title. (a) Ribavirin bound to Coronavirus 2019 (COVID-19) PLpro via aromatic interaction with residue Y265 and hydrogen bonding with residues G164, D165, and Y269 [113]. (B) Binding of remdesivir to the COVID-19 nsp12–nsp7–nsp8 complex [Protein Data Bank (PDB) 7bv2], where the binding pocket is formed by residues D623, S682, T687, A688, and D760 through hydrogen bonding [114]. (C) Binding of chloroquine to the N-terminal domain of SARS-Cov-2 Spike protein (PDB 6vsb) [115]. (D) Binding of lopinavir to the protease model through Q98, T103, and R141 [116].