Figure 3.

Cone visualization in AOSLO images. A. An image showing well-resolved cones was taken in the eye of a normal subject (AREDS AMD grade 1). Hyporeflective bands are shadows cast by a retinal capillary (green arrowheads). Cones are manifest as reflective dots packing in a contiguous mosaic pattern (red arrowheads). B. An image with unresolved cones taken in the eye of a normal subject (AREDS grade 1). While a retinal vessel is imaged (green arrowheads), a cone mosaic is not visible. C. An image showing resolved cones taken in the eye of a patient with AREDS grade 8. Although cones lose reflectivity due to perturbation by subretinal drusenoid deposits (stage 3, magenta arrowheads; stage 1, white arrows), the characteristic cone mosaic is still visible outside the area directly affected by the lesion (red arrowheads). D. An image showing resolved cones taken in the eye of a patient with AREDS grade 7. Characteristic cone mosaic (red arrowheads) is visible outside an atrophic area (yellow arrowheads). All the images are 1° × 1° and were acquired at approximately 2° superior to the foveal center. Corresponding pupil images and lens clarity of these eyes are shown in Figure 5.