Figure 1.
Systemic MSC administration reduces clinical EAE scoring. (A) Untreated MOG35-55-induced EAE mice (black: EAE) display a moderate EAE disease course by means of a five-scale EAE scoring system whereas sham-immunized control mice (blue: CTRL) show no signs of motor-sensory impairment over time. EAE mice having received as single systemic injection of 106 human MSC (green: EAE + MSC) at day seven after EAE induction (arrow) demonstrate a milder disease course when compared to untreated EAE mice. Mean EAE scores per day with SEM are given and * indicates P < 0.05. (B) Area under curve (AUC) analysis obtained from MSC-treated and untreated EAE mice demonstrate significantly lower overall disease severity (mean ± SEM) in MSC-treated EAE mice. Weakening of the tail or any other signs of motor-sensory impairment were not observed in sham-immunized controls.