Figure 3.

MSC treatment mitigates RNFL thinning in EAE mice. (A) Thickness of the RNFL (dotted yellow lines) was determined in 4 quadrants at 400 µm distance from the center of the optic nerve head (OHN). (B) Treatment of EAE mice with MSC at day 7 leads to preservation of the RNFL thickness when compared to untreated EAE mice, measured 32 days after EAE induction. (C) Representative OCT images from EAE mice and MSC-treated EAE mice show differences in RNFL thickness. Note overall thicker RNFL, with areas of RNFL hypertrophy (between asterisks) and enlarged blood vessels (arrows) in MSC-treated EAE mice.