Table 2.
Salvage treatment characteristics.
| Na (total = 22) | % | |
|---|---|---|
| Re-irradiation type | ||
| Brachytherapy alone | 11 | 50.0% |
| EBRT + brachytherapy | 11 | 50.0% |
| Median re-irradiation pelvic EBRT dose (Gy) (range) | 45 (24–45) | |
| Brachytherapy technique | ||
| MCVC | 11 | 50.0% |
| MCVC with free-hand needles | 2 | 9.1% |
| Interstitial | 8 | 36.4% |
| Single-channel vaginal cylinder | 1 | 4.5% |
| Re-irradiation brachytherapy regimens (intracavitary) | ||
| 30 Gy in 6 fractions | 6 | 27.3% |
| Other | 8 | 36.4% |
| Re-irradiation brachytherapy regimens (interstitial) | ||
| 25 Gy in 5 fractions | 4 | 18.2% |
| 22.5 Gy in 5 fractions | 2 | 9.1% |
| 27.5 Gy in 5 fractions | 1 | 4.5% |
| 31.7 Gy in 7 fractions | 1 | 4.5% |
| Median HRCTV (cc) (IQR) | 23.2 (13.0–30.6) | - |
| Median HRCTV D90, EQD2 (Gy) (IQR) | 64.5 (49.6–75.8) | - |
| Median cumulative D2cc, EQD2 (Gy) (IQR) | ||
| Bladder | 72.1 (30.3–81.8) | - |
| Rectum | 70.6 (32.0–80.5) | - |
| Sigmoid colon | 52.7 (29.6–75.3) | - |
| Salvage surgery | ||
| Yes | 5 | 22.7% |
| No | 17 | 77.3% |
| Salvage chemotherapy | ||
| Sequential | 5 | 22.7% |
| Concurrent | 3 | 13.6% |
| None | 14 | 63.6% |
| Salvage hormonal therapy | 3 | 13.6% |
a
Unless otherwise specified. EBRT — external beam radiation therapy. MCVC = multichannel vaginal cylinder. HRCTV = high-risk clinical target volume. EQD2 = equivalent dose in 2-Gy fractions. IQR interquartile range.