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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Arch Pathol Lab Med. 2019 Sep 4;144(3):344–349. doi: 10.5858/arpa.2019-0093-CP

Table 4.

Analytical Sensitivity and Specificity of RNA and DNA In Situ Hybridization (ISH) on Proficiency Testing Samples

Performance Results
ISH Type TP TP + FN Sensitivity, % (95% CI) P Valuea
RNA 334 345 96.8 (94.4–98.4) <.001
DNA 451 603 74.8 (71.1–78.2)
TN TN + FP Specificity, % (95% CI)
RNA 116 117 99.1 (95.3–99.9) .44
DNA 199 203 98.0 (95.0–99.5)

Abbreviations: FN, false negative; FP, false positive; TN, true negative; TP, true positive.

a

χ2 test. Boldface indicates statistical significance.