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Summary of Inhibition of Microsomal Recombinant CYP2A6 by E-Liquid Flavoring Agents
| Lowest Concentration Tested |
Highest Concentration Tested | Flavoring Agent | IC50 of 3-cyano coumarin 7-hydroxylation | IC50 95% confidence interval (lower limit-upper limit) |
|---|---|---|---|---|
| 0.03 μM | 500 μM | Isoamyl Acetate | > 500 μM | -- |
| 0.03 μM | 500 μM | Vanillin | 70.0 μM | 46.5–164 μM |
| 0.03 μM | 500 μM | Ethyl vanillin | 69.4 μM | 57.0–89.3 μM |
| 0.03 μM | 500 μM | Benzaldehyde | 3.0 μM | 1.6–5.5 μM |
| 0.03 μM | 500 μM | Cinnamaldehyde | 1.1 μM | 0.65–1.7 μM |
