. Author manuscript; available in PMC: 2021 Jul 20.

Published in final edited form as: Chem Res Toxicol. 2020 Jun 18;33(7):1689–1697. doi: 10.1021/acs.chemrestox.9b00514

Table 3.

Identified Vs. Expected microsomal recombinant IC₅₀ values of E-liquids.

E-Liquid Flavoring	Primary Flavoring Agent	Measured IC₅₀ of Primary Flavoring Agent	Concentration of Flavoring Agent in E-liquid	Expected IC₅₀ of E- liquid Based on Flavoring IC₅₀ and Concentration	Identified IC₅₀ of E-liquid
Flamethrower	Cinnamaldehyde	1.1 μM	295 mM	0.00037%	0.00038%
Strawberry Poptart	Vanillin Ethyl vanillin	Vanillin: 70 μM Ethyl Vanillin: 69.4 μM	Vanillin: 26.4 mM Ethyl vanillin: 7.3 mM	0.21% (additive)	0.0058%