Table 2.
Impact of second-tier analysis on false positive cases and PPV values. Babies with confirmed B12 deficiency are included. Within parenthesis are the numbers when babies with vitamin B12 deficiency are counted as false positives.
| Before or after Second-Tier | Time Period | All Recalls | True Positive Cases | False Positive Cases | PPV | Number of Screened Newborns in Period |
|
|---|---|---|---|---|---|---|---|
| IVA | Before | 15 Nov. 2010–08 Dec. 2010 | 11 | 0 | 11 | 0% | 7334 |
| After | 09 Dec. 2010–1 Jul. 2019 | 7 | 6 | 1 | 86% | 993,000 | |
| HCY | Before | 15 Nov. 2010–31 Dec. 2016 | 13 | 1 | 12 | 8% | 706,543 |
| After | 1 Jan. 2017–1 Jul. 2019 | 2 | 2 | 0 | 100% | 293,791 | |
| MMA/PA | Before | 15 Nov. 2010–31 Dec. 2016 | 139 | 47 (8) | 92 (131) | 34% (6%) | 706,543 |
| After | 1 Jan. 2017–1 Jul. 2019 | 26 | 16 (7) | 10 (19) | 62% (27%) | 293,791 |