Table 2. Manually curated biologically relevant search results for interactors coevolving with van Hooff et al.’s kinetochore and APC selected protein families [10].

Protein families returned within clusters containing query HOGs are listed with their pertinent annotation and literature. This is a non-exhaustive summary of some selected results. The full enrichment results are available as S1 Data.

Cluster	Result	GO Term	Citation
APC1	CFAP157	GO:0035082 axoneme assembly	[33]
APC12	C2CD3	GO:0061511 centriole elongation	[34]
CenpQ	ESCO2	GO:0007059 chromosome segregation	[35]
KNL1	TACC3	GO:0007091 metaphase/anaphase transition of mitotic cell cycle	[36]