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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 10;1864(10):1396–1411. doi: 10.1016/j.bbalip.2019.05.014

Fig. 6.

Fig. 6.

PPARα activation by Wy treatment suppresses FXR signaling through RXRα competition. A. Hepatic mRNA expression of PPARα and its target genes. B. Hepatic mRNA expression of genes involved in regulating BA homeostasis. C. Intestinal Ppara mRNA expression and its target genes. D. Intestinal mRNA expression of genes involved in regulating BA homeostasis. E. Luciferase activity of vehicle-, Wy-, and CDCA-treated AML12 cells co-transfected with PPRE-luc reporter and empty vector, FXR, PPARα, and/or RXRα expression vectors. F. Luciferase activity of vehicle-, CDCA-, and Wy-14,643-treated AML12 cells co-transfected with SHP-luc reporter and empty vector, FXR, PPARα and/or RXRα expression vectors. Data are presented as mean ± SEM; n = 6/group. *P < 0.05 or **P < 0.01, by one-way ANOVA followed by Tukey’s post-hoc correction.