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. 2020 Jul 27;375(1807):20190387. doi: 10.1098/rstb.2019.0387

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Cellular mechanisms of the three ‘rules’ of collective migration. (a) Two colliding cells (black dotted lines) repolarize and move away from each other (black arrows) by contact inhibition of locomotion. Purple regions represent the local activity of Rac1 at the leading edge and brown regions represent the local activity of RhoA at the cell rear. (b) Two cells are mutually attracted by C3a-dependent chemotaxis. (c) Two colliding cells move together for a short period of time after colliding, and before repulsion. This is one mechanism that drives the alignment of cell motion.