Figure 4.

Efficient wound closure and dynamic heterogeneity. (a) Representative phase contrast images and corresponding leader and non-leader cell tracks in monolayers at low and high SDH scenarios, showing wound closure is much slower at lower SDH. (b) Representative individual cell tracks of leader and non-leader cells at low (i) and high (ii) SDH, showing cells migrating much further at higher SDH. (c) Average cellular persistence (i) and average velocity (ii) at low and high density showing both leaders and non-leader cells are more persistent and migrate faster at high SDH. Further, leader cells showed significantly higher persistence and higher velocity than non-leaders at high SDH, while at low SDH, difference between leaders and non-leaders was found to be insignificant.