Figure 2.
Deregulated genes during the ageing process. (a) Fraction of genes differentially expressed in the three species (MMU = M. musculus; DRE = D. rerio; NFU = N. furzeri) in at least one time point. (b) Probability that, at each time, genes differentially expressed are randomly distributed along the genome. The distribution of genomic distances between differentially regulated genes has been compared with the distribution obtained from random sampling of expressed genes for each species. The heatmap reports the average p-value obtained comparing the distributions of inter-gene distances using the Kolmogorov–Smirnov test (103 replica) Higher p-values indicate a distribution close to the null-model random distribution.