Change in glycolysis efficiency over time. Barplots displaying the change in glycolysis efficiency, defined as the ratio of glucose to pyruvate transformation, as estimated by the constraint-based metabolic model. The bars show the relative change in efficiency at a given time point T with respect to the initial time T0 for N. furzeri (green), zebrafish (blue), mouse (pink) and three different tissues: liver (a), skin (b) and brain (c). Overall, the figure shows how NFU increases its efficiency during its lifetime. MMU = M. musculus; DRE = D. rerio; NFU = N. furzeri.