Figure 5.

Relative error of inferred mean transcription rates with deterministic models at a genomic scale. (a) Relative error in the inferred transcription rate for the 5028 genes reported in [33], as a function of the relative degradation rate η and the reported transcription rate. The relative errors are calculated between different models with stochastic cell cycle and the deterministic cell cycle model without replication used in [33] (see appendix F). Discrepancies between models are a function of η (dotted line). (b) Histogram showing the number of genes for different levels of transcription rate error for three different stochastic cell cycle models. The stochastic cell cycle used is an Erlang model with k = 0.145 h⁻¹ and N = 16 using the reported cell cycle duration and variability in [33] (see appendix F), while replication is considered to occur at the middle of the cell cycle (w = 1/2).