Table E1.
Asthma groups and PRS models∗ | OR (95% CI) | P value |
---|---|---|
Asthma (overall) PRS† | 1.09 (0.97-1.21) | .15 |
Asthma (overall) PRS‡ | 1.06 (0.97-1.17) | .21 |
Allergic asthma PRS‡ | 1.04 (0.94-1.14) | .45 |
Nonallergic asthma PRS‡ | 1.06 (0.97-1.16) | .22 |
Asthma with COPD PRS‡ | 1.03 (0.94-1.13) | .51 |
Asthma without COPD PRS‡ | 1.06 (0.96-1.16) | .23 |
ORs and 95% CIs (per 1 Z score of the corresponding PRS) were estimated by logistic regression models adjusting for age, sex, body mass index, genotyping array, and 30 ancestry principal components in the corresponding GWAS.
Asthma (overall) PRS was computed using the TAGC data set.
PRSs for asthma (overall) and 4 asthma phenotypes were computed using the UK Biobank data set.