Table E1.

Multivariable associations between asthma PRSs and risks of severe COVID-19

Asthma groups and PRS models∗	OR (95% CI)	P value
Asthma (overall) PRS†	1.09 (0.97-1.21)	.15
Asthma (overall) PRS‡	1.06 (0.97-1.17)	.21
Allergic asthma PRS‡	1.04 (0.94-1.14)	.45
Nonallergic asthma PRS‡	1.06 (0.97-1.16)	.22
Asthma with COPD PRS‡	1.03 (0.94-1.13)	.51
Asthma without COPD PRS‡	1.06 (0.96-1.16)	.23

^∗ORs and 95% CIs (per 1 Z score of the corresponding PRS) were estimated by logistic regression models adjusting for age, sex, body mass index, genotyping array, and 30 ancestry principal components in the corresponding GWAS.

^†Asthma (overall) PRS was computed using the TAGC data set.

^‡PRSs for asthma (overall) and 4 asthma phenotypes were computed using the UK Biobank data set.