Table E2.

Discriminatory performance (area under the receiver-operating characteristic curve) of PRS, according to different models

Asthma groups	PRS model with different priors on fraction causal markers
	0.001	0.003	0.01	0.03	0.1	0.3	1.0
Asthma (overall) PRS∗	0.510	0.517	0.582	0.576	0.569	0.566	0.564
Asthma (overall) PRS†	0.516	0.535	0.570	0.626	0.612	0.603	0.599
Allergic asthma PRS†	0.597	0.558	0.600	0.605	0.596	0.590	0.586
Nonallergic asthma PRS†	0.554	0.561	0.566	0.563	0.559	0.557	0.556
Asthma with COPD PRS†	0.549	0.561	0.565	0.564	0.564	0.564	0.564
Asthma without COPD PRS†	0.597	0.531	0.571	0.603	0.593	0.586	0.583

Results in boldface are the highest area under receiver-operating characteristic curve value to discriminate the corresponding asthma group among the 7 models for each asthma group.

^∗Asthma (overall) PRS was computed using the TAGC data set.

^†PRSs for asthma (overall) and 4 asthma phenotypes were computed using the UK Biobank data set.