Table E2.
Asthma groups | PRS model with different priors on fraction causal markers |
||||||
---|---|---|---|---|---|---|---|
0.001 | 0.003 | 0.01 | 0.03 | 0.1 | 0.3 | 1.0 | |
Asthma (overall) PRS∗ | 0.510 | 0.517 | 0.582 | 0.576 | 0.569 | 0.566 | 0.564 |
Asthma (overall) PRS† | 0.516 | 0.535 | 0.570 | 0.626 | 0.612 | 0.603 | 0.599 |
Allergic asthma PRS† | 0.597 | 0.558 | 0.600 | 0.605 | 0.596 | 0.590 | 0.586 |
Nonallergic asthma PRS† | 0.554 | 0.561 | 0.566 | 0.563 | 0.559 | 0.557 | 0.556 |
Asthma with COPD PRS† | 0.549 | 0.561 | 0.565 | 0.564 | 0.564 | 0.564 | 0.564 |
Asthma without COPD PRS† | 0.597 | 0.531 | 0.571 | 0.603 | 0.593 | 0.586 | 0.583 |
Results in boldface are the highest area under receiver-operating characteristic curve value to discriminate the corresponding asthma group among the 7 models for each asthma group.
Asthma (overall) PRS was computed using the TAGC data set.
PRSs for asthma (overall) and 4 asthma phenotypes were computed using the UK Biobank data set.