TABLE 2.
Risk Factors Associated With Anthracycline-Related Cardiomyopathy
| Risk Factor | OR (95% CI) | Pa |
|---|---|---|
| Age at primary cancer diagnosis, y | ||
| Per y increase in age | 0.95 (0.88-1.01) | .1 |
| Anthracycline dose, mg/m2b | ||
| <250 | 1.00 | |
| ≥250 | 2.5 (0.99-6.4) | .05 |
| Chest radiation | ||
| No | 1.00 | |
| Yes | 1.5 (0.6-3.6) | .4 |
| Sex | ||
| Male | 1.00 | |
| Female | 1.5 (0.7-2.9) | .3 |
| Genotype | ||
| GSTM1 positive | 1.00 | |
| GSTM1 null | 2.7 (1.3-5.9) | .007c |
Abbreviations: GSTM1, glutathione S-transferase μ1; OR, odds ratio.
a
P values were estimated from a conditional logistic regression model that included age at cancer diagnosis, sex, chest radiation and anthracycline exposure (categorical).
b
Doses were not available for 1 case and 1 control.
c
This P value indicates a significant difference.