TABLE 3.
Demographic and Clinical Characteristics by Case-Control Status for Gene Expression Analysis
| Variable | Cases, N = 20 | Controls, N = 20 | Pa |
|---|---|---|---|
| Age at primary cancer diagnosis, y | |||
| Mean ± SD | 6.6 ± 5.4 | 7.5 ±5.8 | .6 |
| Median [range] | 5.5 [1.9-9.2] | 6.4 [1.4-13.2] | .8 |
| Sex: No. (%) | |||
| Female | 10 (50.0) | 8 (40.0) | .5 |
| Cumulative anthracycline exposure, mg/m2 | |||
| Mean ± SD | 304.6 ± 116.9 | 198.1 ±81.9 | .002c |
| Median [range] | 295 [240.7-350.0] | 217.5 [121.3-266.3] | .002c |
| Chest radiation | |||
| Yes: No. (%) | 7 (35.0) | 7 (35.0) | 1.0 |
| Dose: Mean ± SD, cGy | 797.5 ± 1280.7 | 725.5 ± 1218.3 | 0.9 |
| Primary diagnosis: | |||
| No. (%) | |||
| ALL | 5 (25.0) | 5 (25.0) | 1.0b |
| HL or NHL | 9 (45.0) | 9 (45.0) | |
| Other | 6 (30.0) | 6 (30.0) | |
| Time from cancer diagnosis, yd | |||
| Mean ± SD | 12.5 ± 5.9 | 16.8 ± 5.7 | .02c |
| Median [range] | 11.4 [8.8-18.0] | 15.9 [12.2-21.2] | .02c |
Abbreviations: ALL, acute lymphoblastic leukemia; cGy, centigrays; HL, Hodgkin lymphoma; NHL, non-Hodgkin lymphoma.
a
P values were estimated using either chi-square tests and t tests for categorical variables or the Wilcoxon test for continuous variables.
b
This P value was determined with the Fisher exact test.
c
This P value indicates a significant difference.
d
The time in years from cancer diagnosis to cardiac event is indicated for cases, and the time in years to enrollment is indicated for controls.