. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Arch Toxicol. 2020 Jun 23;94(9):3125–3136. doi: 10.1007/s00204-020-02816-0

Table 2.

Effects of AZD9291 and/or ABT263/ABT199 on cell cycles of H1975AR

Groups	Cell Cycle (%)
Groups	pre-G1	G0/G1	S	G2/M
Control	3.1±0.25^a	65.5±2.31^a	4.0±1.19^a	23.6±0.54^a
AZD2.5	4.6±1.15^b	68.2±1.67^a	3.0±0.07^a	22.0±3.62^a
AZD5	4.3±0.36^b	69.3±0.77^b	3.9±0.21^a	19.8±2.66^b
ABT263 0.25	5.6±0.31^b	60.3±0.82^b	3.0±0.38^a	28.2±0.38^b
ABT263+AZD2.5	6.3±0.70^b,c	63.2±2.29^a,c	4.2±0.44^a,d	23.2±2.52^a,c
ABT263+AZD5	8.8±1.92^b,d	62.9±1.14^a,c	3.9±1.12^a,c	22.0±2.29^a,c
ABT199 1.0	4.0±0.44^b	64.1±0.72^a	3.0±0.55^a	27.9±1.86^b
ABT199+AZD2.5	4.7±0.77^b,c	69.7±0.15^b,c	3.0±0.22^a,c	20.0±1.94^b,c
ABT199+AZD5	6.5±1.70^b,d	73.7±0.86^b,d	3.0±0.54^a,c	14.9±1.13^b,d

Data are represented as mean ± SD (n = 3). Mean values within the same column containing different superscript letters indicates significance among the treatment groups analyzed by one-way ANOVA followed by a Fisher’s LSD test (p < 0.05). Values bearing the letter “a” indicate no significant differences compared with control, those labeled “b” denote a significant difference (p<0.05) when compared with the control, “c” denotes no significant difference when AZD9291+ABT263/ABT199 is compared with either AZD9291 or ABT263/ABT199 treatment alone at the corresponding concentration, and “d” denotes a significant difference (p<0.05) when AZD9291+ABT263/ABT199 is compared with AZD9291 as well as ABT263/ABT199 treatment alone at the corresponding concentration.