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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: Cancer Cell. 2020 Jun 25;38(2):247–262.e11. doi: 10.1016/j.ccell.2020.05.018

Figure 7. Low PKCλ/ι Expression in Human Liver Tissue is a Risk Factor for Late HCC Recurrence.

Figure 7.

(A) H&E staining and IHC for PKCλ/ι in clinical HCC sections of different histological grade (n = 271 cases) and surrounding non-tumorous (NT, n = 143 cases) liver tissues. Scale bar, 100 μm.

(B) PKCλ/ι expression levels in HCC according to the IHC based classification; none, weak, moderate and strong (NT, n = 143; HCC, n = 271).

(C) Univariate and multivariate analyses to determine risk factors associated with HCC grade (odds ratio; poorly differentiated HCC vs HCC of well or moderately differentiated HCC), (n = 143).

(D) Kaplan-Meier curves of time to late recurrence in patients who underwent surgical resection of HCC. Patients were classified according to the PKCλ/ι expression level in surrounding non-tumorous liver tissues (n = 82).

(E) Negatively correlated pathways to Prkci gene expression in background liver tissues of HCC patients from TCGA dataset using compilation H and C5 (MSigDb).

(F-G) GSEA of the indicated genesets.

(H) Negative correlation between Prkci gene expression in background liver tissues of HCC patients from TCGA dataset with PPARα and NRF2 targets (C3, MSigDb).

*p < 0.05, **p < 0.01.