. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: J Heart Lung Transplant. 2020 Feb 13;39(9):880–890. doi: 10.1016/j.healun.2020.02.004

Table 3.

Multivariable Adjusted Associations Between Shannon Index (Alpha Diversity) and Measures of Inflammation, Endotoxemia, and Oxidative Stress

	Regression coefficient	p-value
C-reactive protein	−0.3396	0.002
Interleukin-6	−0.1546	0.04
Tumor necrosis factor-alpha	−0.1381	0.0002
Endothelin-1	−0.0490	0.19
Adiponectin	−0.1283	0.03
Lipopolysaccharide	−0.0405	0.04
sCD14	0.0005	0.98
Isoprostane	0.0378	0.39

sCD14, soluble CD14.

All analyses from mixed models adjusted for age, sex, and race/ethnicity. All biomarkers (except lipopolysaccharide) required LN transformation before regression analysis. Regression coefficients represent the difference in biomarker level for every 1 unit increase in Shannon Index. For reference, the standard deviation of the Shannon Index = 0.69 in this patient sample.