Mean (±SEM) physical signs (A), % time in the open arms (B), % time in the lit compartment (C), and corticosterone levels (D) in male (0 n=16; 1.5 n=17; 3.0 n=12), intact female (0 n=18; 1.5 n=24; 3.0 n=38), and OVX (0 n=13; 1.5 n=12; 3.0 n=13) rats. Asterisks (*) denote a difference from respective saline controls, number signs (#) denote a difference from their respective mecamylamine-treated group, at signs (@) denote a difference from OVX rats in their respective treatment condition, and the dagger (†) denotes a difference from males and OVX rats in their respective treatment condition (p≤0.05).