Mean (±SEM) physical signs (A), % time in the open arms (B), % time in the lit compartment (C) and corticosterone (D) levels following administration of mecamylamine (3.0 mg/kg) in nicotine-treated intact females that were tested in the proestrus (n=12), estrus (n=12), metestrus (n=7), or diestrus (n=7) phase of the estrous cycle. Daggers (†) denotes a difference from all other groups (p≤0.05).