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. 2020 Jan 24;270(6):771–782. doi: 10.1007/s00406-020-01098-y

Table 2.

Results from regression analysis of hippocampal subfield and amygdala nuclei volumes in SCZ-V, SCZ-NV, and HC

Region SCZ-NV vs HC SCZ-V vs HC SCZ-V vs SCZ-NV
p value Effect size p value Effect size p value Effect size
Whole hippocampus 0.144 − 0.325 0.02 − 0.664 0.503 − 0.279
 Parasubiculum 0.789 − 0.05 0.168 − 0.332 0.503 − 0.324
 Presubiculum 0.575 − 0.154 0.061 − 0.47 0.503 − 0.344
 Subiculum 0.64 − 0.114 0.075 − 0.444 0.503 − 0.34
 CA1 0.097 − 0.394 0.009 − 0.712 0.503 − 0.289
 CA3 0.176 − 0.289 0.879 0.045 0.503 0.311
 CA4 0.144 − 0.323 0.332 − 0.251 0.881 0.063
 GCMLDG 0.097 − 0.423 0.17 − 0.361 0.881 0.055
 HATA 0.097 − 0.376 0.009 − 0.803 0.503 − 0.419
 Fimbria 0.136 − 0.328 0.009 − 0.711 0.503 − 0.396
 Molecular layer 0.097 − 0.374 0.025 − 0.635 0.654 − 0.213
 Hippocampal fissure 0.097 0.379 0.009 0.793 0.503 0.384
 Hippocampal tail 0.691 − 0.079 0.067 − 0.53 0.503 − 0.361
Whole amygdala 0.051 − 0.505 0.033 − 0.553 0.881 − 0.072
 Lateral nucleus 0.097 − 0.407 0.102 − 0.426 0.957 − 0.025
 Basal nucleus 0.046 − 0.571 0.009 − 0.678 0.81 − 0.133
 Accessory basal nucleus 0.064 − 0.468 0.033 − 0.544 0.861 − 0.11
 Anterior amygdaloid area 0.097 − 0.383 0.163 − 0.364 0.987 0.003
 Central nucleus 0.644 0.104 0.179 0.32 0.654 0.224
 Medial nucleus 0.617 0.124 0.061 0.477 0.503 0.386
 Cortical nucleus 0.617 − 0.122 0.879 0.034 0.776 0.165
 Corticoamygdaloid transition area 0.051 − 0.505 0.009 − 0.667 0.69 − 0.215
 Paralaminar nucleus 0.046 − 0.545 0.009 − 0.69 0.776 − 0.15

Effects of diagnostic group (SCZ-V, SCZ-NV, and HC) on hippocampal subfield and amygdala volumes were tested using general linear model by creating three pairwise contrasts (SCZ-NV versus HC, SCZ-V versus HC, SCZ-V versus SCZ-NV) covarying for age, age2, sex, intracranial volume (ICV), and scanning site. All p values are FDR corrected for multiple comparisons. Bold p values indicate significant differences between groups. Effect sizes are calculated with Cohen´s D

SCZ-V schizophrenia patients with a history of violence, SCZ-NV schizophrenia patients with no history of violence, HC healthy controls, CA cornu ammonis, GCMLDG granule cell layer of the dentate gyrus, HATA hippocampal–amygdaloid transition area